Folate Transport in Mouse Cumulus-Oocyte Complexes and Preimplantation Embryos1
نویسندگان
چکیده
منابع مشابه
Successful preimplantation genetic diagnosis is related to the number of available cumulus-oocyte complexes.
The inheritance pattern of monogenic inheritable disorders influences the proportion of unaffected embryos after preimplantation genetic diagnosis (PGD). We aimed to investigate the influence of the number of cumulus-oocyte complexes (COC) on the outcome after PGD. Eighty-four cycles of 47 couples were included in our analysis. All couples were at risk of transmitting autosomal recessive, autos...
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Background: In vitro maturation is a good method to decrease cancer risk of superovulation by gonadotropin hormones. A paracrine effect of oocyte secretions on oocyte developmental competence is under investigation. Apart from oocyte maturation, ovulation in vivo requires a precise control of extracellular matrix modification. Cumulus cells secrete hyaluronan to form a muco-elastic extracellula...
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cAMP and intracellular Ca2+ are important second messengers involved in mammalian follicular growth and oocyte meiotic maturation. We investigated the capacity of the neurohormone serotonin (5-hydroxytryptamine, 5-HT) to regulate intracellular cAMP and Ca2+ in mouse oocytes and surrounding cumulus cells. On the basis of a reverse transcription-polymerase chain reaction study, 5-HT7 receptor mRN...
متن کاملProgesterone-mediated effects on gene expression and oocyte-cumulus complex transport in the mouse fallopian tube
BACKGROUND The fallopian tube transports the gametes to the fertilization site and delivers the embryo to the uterus at the optimal time for implantation. Progesterone and the classical progesterone receptor are involved in regulating both tubal ciliary beating and muscular contractions, likely via both genomic and non-genomic actions. METHODS To provide more details of the underlying mechani...
متن کاملOocyte-dependent activation of MTOR in cumulus cells controls the development and survival of cumulus-oocyte complexes.
Communication between oocytes and their companion somatic cells promotes the healthy development of ovarian follicles, which is crucial for producing oocytes that can be fertilized and are competent to support embryogenesis. However, how oocyte-derived signaling regulates these essential processes remains largely undefined. Here, we demonstrate that oocyte-derived paracrine factors, particularl...
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ژورنال
عنوان ژورنال: Biology of Reproduction
سال: 2013
ISSN: 0006-3363,1529-7268
DOI: 10.1095/biolreprod.113.111146